Panama City Beach, Florida
7/20All you need to know is that the MTV reality TV series "Floribama Shore" takes place in Panama City Beach. Plus, it's home to Club La Vela, which bills itself as the world's largest nightclub. Oh yeah, and the region is home to 27 miles of sun-kissed, white-sand beaches. Spring break travelers will also have a ton of exciting events and festivals to look forward to this year, including the Emerald Coast Boat and Lifestyle Show (March 15-17), UNwineD (March 22-23), the Seabreeze Jazz Festival (April 24-28) and the Thunder Beach Spring Motorcycle Rally (May 1-5), among many others.